This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone.Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Target	ESR1
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, IHC, IF/ICC
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human ESR1 expressed in E. coli.
Purification	Unpurified Ascites.
Isotype	IgG1
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	66 kDa
Swiss Prot	P03372
GeneID	2099
Gene Symbol	ESR1
OMIM	133430
HGNC	3467
Ensembl	ENSG00000091831
Buffer	Ascitic fluid containing 0.03% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.