Akt3 (also designated protein kinase B gamma or v-akt murine thymoma viral oncogene homolog 3), with 479-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt2. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.Akt3 is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. Identifying Akt3 as a selective target in melanoma cells also provides new therapeutic opportunities for patients in the advanced stages of this disease.

Target	Akt3
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of Akt3 expressed in E. Coli.
Purification	Unpurified Ascites.
Conjugation	Unconjugated
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight	55 kDa
Swiss Prot	Q9Y243
GeneID	10000
Gene Symbol	AKT3
OMIM	611223
Enzyme Commission Number	EC 2.7.11.1, EC 2.7.11
HGNC	393
Ensembl	ENSG00000117020
Buffer	Ascitic fluid containing 0.03% sodium azide.
UNSPSC Code	12352203
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.