Flow Cytometry: 1/200 - 1/400, Western Blot: 1/500 - 1/2000
Reviews / Ratings
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Description
TAB2 Monoclonal Antibody (3B5). The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB , which may regulate the development and function of osteoclasts.