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Description
Mouse monoclonal antibody to CD49f. The GoH3 monoclonal antibody reacts with mouse and human CD49f, also known as integrin alpha 6, very late activation antigen 6 (VLA-6 alpha chain), and platelet gpIc. CD49f is a 120 kD transmembrane protein. CD49f associates with CD29, the integrin beta 1 chain, to form the VLA-6 compleX; CD49f also associates with CD104, the integrin beta 4 chain, to form the alpha 6 beta 4 compleX. CD49f is eXpressed primarily on T cells, monocytes, platelets, epithelial and endothelial cells. CD49f eXpression has also been found on germinal center B cells. The GoH3 antibody is cross-reactive to integrin alpha 6 on human, mouse and bovine cells. This antibody has also been reported to have functional activity in blocking the binding of integrin alpha 6 to laminin.