Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2000
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Description
S100A12 Polyclonal Antibody. S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated
Immunogen
n/a
Other Names
CAAF1;CAGC;Calcitermin;Calcium binding protein in amniotic fluid;Calcium-binding protein in amniotic fluid 1;Calgranulin C;Calgranulin related protein;Calgranulin-C;CGRP;EN RAGE;EN-RAGE;ENRAGE;Extracellular newly identified RAGE-binding protein;MRP6;Neutrophil S100 protein;p6;Protein S100 A12;S100 calcium binding protein A12;S100 calcium-binding protein A12;S100A12;S10AC_HUMAN;