Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000
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Description
BAG3 Polyclonal Antibody. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Immunogen
n/a
Other Names
BAG-3, BIS, CAIR-1, BAG family molecular chaperone regulator 3, BAG-family molecular chaperone regulator-3, BCL2-binding athanogene 3, bcl-2-associated athanogene 3, bcl-2-binding protein Bis, docking protein CAIR-1