Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:5000
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Description
Twist1/Twist2 Polyclonal Antibody. Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.
Immunogen
n/a
Other Names
ACS3, B-HLH DNA binding protein, BPES2, BPES3, CRS1, DERMO1, H-twist, MGC117334, SCS, TWIST, TWIST homolog of drosophila, TWIST1, TWIST2, bHLHa38, bHLHa39, class A basic helix-loop-helix protein 38, class A basic helix-loop-helix protein 39, dermis-expressed protein 1, twist homolog 2 (Drosophila), twist-related bHLH protein Dermo1, twist-related protein 1, twist-related protein 2