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Description
Mouse Anti-LYPD8 Recombinant Antibody (CBYJL-2247). Provided herein is a Mouse monoclonal antibody, which binds to Ly6/Plaur Domain Containing 8 (LYPD8). The antibody can be used for immunoassay techniques, such as FC, ICC. LYPD8 is a secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. LYPD8 prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
Immunogen
Human embryonic kidney cell line HEK293-derived transfected with human LYPD8, Met1-Asn215, Accession # Q6UX82.