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Description
Mouse Anti-LYPD6B Recombinant Antibody (634CT7.10.1). Provided herein is a Mouse monoclonal antibody, which binds to Ly6/Plaur Domain Containing 6B (LYPD6B). The antibody can be used for immunoassay techniques, such as ELISA, WB. LYPD6B is believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-33:beta-42 nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-32:alpha-5:beta-42 nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.
Immunogen
LYPD6B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-109 amino acids from the Central region of human LYPD6B.