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Description
Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor 488. Initially only transmembrane protein known to be associated with tight junctions was occludin, an ~65 kDa protein with four transmembrane domains. Despite widespread expectation, a critical structural role for occludin in TJ strands was ruled out by the observation of apparently normal tight junctions formed between cells disrupted at both occludin alleles. A closer examination of isolated tight junctions uncovered two related ~22 kDa, four-transmembrane domain proteins, claudin-1 and claudin-2, with no similarity to occludin. In contrast to occludin, which induces only a small number of short strands at cell-cell contact sites when introduced into fibroblasts lacking tight junctions,
Immunogen
n/a
Other Names
AWAL, BEC1, CPETRL1, TMVCF, TMDVCF, claudin-5, transmembrane protein deleted in VCFS, transmembrane protein deleted in velocardiofacial syndrome