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Description
JAK3 Monoclonal Antibody (5H2). The protein encoded by this gene is a member of the Janus kinase family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID .