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Description
c-Fos (Thr325) Polyclonal Antibody, Alexa Fluor? 647 Conjugated. ? Target Background: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an imp
Immunogen
KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Thr325. Immunogen Range: 300-350/380