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Description
CDKN1B (Ser178) Polyclonal Antibody. ? Target Background: Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosph
Immunogen
KLH conjugated synthetic phosphopeptide derived from human CDKN1B around the phosphorylation site of Ser178 [DG(p-S)PN]