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Description
DR6 Polyclonal Antibody. ? Target Background: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further
Immunogen
KLH conjugated synthetic peptide derived from human DR6. Immunogen Range: 140-170/655
Other Names
DR6; CD358; BM-018; Tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFRSF21; UNQ437/PRO868