Recombinant Human Glutaminyl-peptide cyclotransferase (QPCT)
Description
Purity > 90% as determined by SDS-PAGE. MW: 53.9kDa. Full Length of Mature Protein: 29-361aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.