Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Biotin-PEG-OH is a linear heterobifunctional reagent with a biotin and an hydroxyl. It is a useful crosslinking or bioconjugation reagent with a PEG spacer. Biotin can bind to avidin and streptavidin with high specificity and affinity.