911-end. MW: 80 kDa. Description: Recombinant human WHSC1 (911-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t (4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2),
Size
0.005 mg, 0.01 mg
Concentration
n/a
Applications
Methyltransferase Assay
Other Names
[Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 1, mRNA; Histone-lysine N-methyltransferase NSD2; histone-lysine N-methyltransferase NSD2; nuclear receptor binding SET domain protein 2; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein]
1. Shah MY, et al: MMSET/WHSC1enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.116. 2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816 (2):158-63.