A diterpenoid with diverse biological activities; inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays (MICs = 39-156 and 312.5-625 μg/ml, respectively); reduces K652 cell viability (IC50 = 18.19 μg/ml); reduces motor deficit, delays disease onset, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th7 cells in a mouse model of EAE at 2 mg/kg; reduces the arthritis index , NF-kB activity, and paw swelling and increases annexin-1 expression in a rat model of collagen-induced arthritis from 1-4 mg/kg; topical administration reduces edema induced carrageenan, CFA, and formalin in rats at 0.3-0.5% w/w