Immunohistochemistry: 2.5 μg/mL, Western Blot: 0.5-1 μg/mL
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Description
PDCD4 Polyclonal Antibody. Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PD
Immunogen
n/a
Other Names
RP11-348N5.4, H731; neoplastic transformation inhibitor protein; nuclear antigen H731; programmed cell death protein 4; protein 197/15a