產(chǎn)品名稱 AGI-5198 from CAYMAN CHEMICAL COMPANY
    產(chǎn)品貨號(hào) 14624-5
    產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
    產(chǎn)品規(guī)格 5 mg
    產(chǎn)品品牌 CAYMAN CHEMICAL COMPANY
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameAGI-5198
    DescriptionSelective inhibitor of IDH1 R132H and R132C mutants in vitro (IC50s = 0.07 and 0.16 μM, respectively) but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 μM); anti-tumor efficacy in vitro and in vivo; induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation
    Size5 mg
    Concentrationn/a
    Applicationsn/a
    Other NamesIDH-C35 IDHC35 IDH C35 inhibitors inhibits inhibitions isocitrates dehydrogenases IDH1 IDH-1 IDH 1 one α-ketoglutarate 2OG 2 OG two 2-OG gliomas antitumor anti tumors anti-tumors 2-hydroxyglutarate hydroxyglutarates HGs 2-HG R132H mutants histones demethylations gliogenesis AGI5198 AGI 5198 potent selectives R132C in vitro TS603 TS-603 xenografts H3K9me3 genes gliogenic differentiations cancers enzymes activity actives metabolisms NADs NADPs NAD-dependent NADP-dependent dependents tricarboxylic acids cycles catalyzes oxidatives decarboxylations alpha ketoglutarates alpha-ketoglutarate carbons dioxides IDH1 IDH2 mutated mutations maps arginines residues catalytic pockets gains of functions NADPH-dependent NADPHs conversion AGI-5198 wild-type wilds types cells lines growths treatments periods induces expressions
    Gene, Accession, CAS #CAS: 1355326-35-0
    Catalog #14624-5
    Price
    Order / More InfoAGI-5198 from CAYMAN CHEMICAL COMPANY
    Product Specific Referencesn/a
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