Recombinant Human 4-1BBL is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion,survival, and development of T cells. In addition, 4-1BBL expression is found on dendritic cells, follicular dendritic cells, naturalkiller cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has been shown to interact with TRAF2.The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a21 amino acid transmembrane domain, and a 205 amino acid extracellular domain (ECD). The human 41BBLECD shares 32 %and 35 % a.a. identity with murine and rat ECD. MW: 19.4 kDa. Purity > 95 % by SDS-PAGE and HPLC analyses.
Size
5 ug, 20 ug, 1 mg, 100 ug, 250 ug, 500 ug
Concentration
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.