28-161aa; Full Length. MW: 19.6kD. Purity >90% as determined by SDS-PAGE. This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chotactic for dendritic cells. Possesses a wide variety of biological activities.
Sequence of human eosinophil-derived neurotoxin cDNAidentity of deduced amino acid sequence with human nonsecretory ribonucleases.Hamann K.J., Barker R.L., Loegering D.A., Pease L.R., Gleich G.J.Gene 83:161-167(1989) Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.Barker R.L., Loegering D.A., Ten R.M., Hamann K.J., Pease L.R., Gleich G.J.J. Immunol. 143:952-955(1989) Molecular cloning of the human eosinophil-derived neurotoxina member of the ribo