Immunocytochemistry: 2 μg/mL, Immunofluorescence: 2 μg/mL, Western Blot: Assay Dependent
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Description
MINA53 Polyclonal Antibody. MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
Immunogen
n/a
Other Names
MDIG, MINA53, NO52, MYC-induced nuclear antigen, mineral dust induced gene protein, mineral dust-induced gene protein, myc-induced nuclear antigen, 53 kDa, nucleolar protein 52