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Description
RhoGDI Monoclonal Antibody (OTI1F2). GDP - Dissociation inhibitors (GDIs) modulate GTPase activity by binding to small G-proteins and regulating GDP/GTP exchange of inflammatory cell activity, including motility, formation of toxic oxygen metabolies and generation of proinflammatory cytokines. RhoGDI may also be critical for the cellular compartmentalization of GTPases. RhoGDI, which can bind to Rho, Rac, and cdc42, is localized in the cytosol. D4GDI, an abundant hematopoietic cell GDI for the Ras-related Rho family GTPases, is a substrate of the apoptosis protease.