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Description
Glycine Binding Protein Polyclonal Antibody. Ionotropic glutamate receptors are oligomeric ion channel proteins, which mediate fast neurotransmission and excitatory synapses in the mammalian central nervous system. There are three distinct subfamilies, of which NMDA receptors have received particular attention because they are implicated in both synaptic plasticity and the pathogenesis of acute and chronic neurodegenerative disorders. A unique feature of the NMDA receptors is their requirement for both glutamate and the co-agonist glycine for efficient gating. Glycine increases the affinity of the receptor for the endogenous agonist glutamate. The glycine binding site is found on the NR1 subunit of the NMDA receptor.