A sulfonamide with anticancer activity (IC50s = 0.11 and 94 μg/ml, for HCT116 and NCI-H596 cells, respectively); increases the number of P388 murine leukemia cells in the G1 phase of the cell cycle in a dose-dependent manner; exerts time-dependent cytotoxicity against HCT116 cells; suppresses tumor growth and decreases tumor volume in murine HCT116, SW620, and HCT15 colorectal and LX-1 and PC9 lung cancer xenograft models; induces proteasomal degradation of RBM39 through association with the CUL4-DCAF15 E3 ubiquitin ligase in vitro; an inhibitor of carbonic anhydrase in H. pylori (Ki = 310-562 nM),