Purity >98%. Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
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Other Names
2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide, BML-277, C 3742, Checkpoint Kinase 2 Inhibitor II