Glial cell line-derived neurotrophic factor (GDNF) was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung's disease. BioVision's GDNF ELISA kit is a sandwich ELISA assay for the quantitative m
Size
100 assays
Concentration
n/a
Applications
This ELISA kit is used for quantitative measurement of total GDNF in human serum, plasma, urine, cell culture samples, biological fluid.