Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Western Blot: 1:500-1:1000
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Description
NECAB3 Polyclonal Antibody. The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Immunogen
n/a
Other Names
APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, EF-hand calcium binding protein 3, N-terminal EF-hand calcium-binding protein 3, Nek2-interacting protein 1, X11L-binding protein 51, amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein, amyloid beta A4 protein-binding family A memb