Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW: 33.8 kDa (302 aa, 35-313 aa + His tag), confirmed by MALDI-TOF. Purity ≥85%
Size
100 μg
Concentration
1 mg/ml
Applications
RUO
Other Names
Membrane cofactor protein isoform 14, AHUS2, MCP, MIC10, TLX, TRA2.10