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Description
LAT Polyclonal Antibody. LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Immunogen
n/a
Other Names
36 kDa phospho-tyrosine adapter protein, 36 kDa phospho-tyrosine adaptor protein, LAT, LAT, LAT1, LAT1, linker for activation of T cells, linker for activation of T cells, transmembrane adaptor, linker for activation of T-cells, linker for activation of T-cells family member 1, p36-38, pp36, pp36