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Description
Merlin (Ser518) Antibody, HRP Conjugated. ? Target Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518. Immunogen Range: 500-545/590