Purity >95%. Lymphocyte-speci?c protein tyrosine kinase (Lck) is a member of the Src-family of non-receptor protein tyrosine kinases and plays a critical role in the initial steps of T cell receptor signaling that trigger the production of cytokines. Lck inhibitor is a pyrrolopyrimidine that blocks the activity of two forms of Lck kinase, Lck (64-509) and Lckcd, with IC50 values of 33, >50, and >50 μM, respectively). This compound has been shown to inhibit T cell receptor-stimulated IL-2 production in mice (ED50 s = 4 and 25 mg/kg when administered either i.p. or orally).
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Other Names
7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Lymphocyte-specific protein tyrosine kinase, RK-24466