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Description
RUNX2(Ser451) Polyclonal Antibody, Alexa Fluor? 647 Conjugated. ? Target Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activa
Immunogen
KLH conjugated synthetic phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451