Purity ≥95% (HPLC). Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents. Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents. Source: Synthetic. Originally isolated from Aspergillus niger FKI-2342. Synonyms: 5-L-Leucine-Malformin A; BRN 4896114; (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]