A potent multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo
Size
50 mg
Concentration
n/a
Applications
n/a
Other Names
KW2449 FLT-3 ABLT3151 Signal transducer activator transcription 5 MOLM13 STAT