A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver; can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety ,,
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
reactive metabolite tamoxifen SERM selective estrogen receptor modulator breast endometrial cancer cytochrome P450 CYP3A4 genotoxic DNA adduct O-sulphonation biochemical damage repair metabolism toxicology reactive reversible hydroxyl hepatocarcinoma