A 5-HT1A receptor agonist (EC50 = 12 nM in rat hippocampal membranes); enhances the behavioral effects of Δ9-THC in rhesus monkeys in a discriminant stimulus-shock test (0.178 mg/kg, i.v.); reduces baclofen-induced aggression in mice when administered directly to the dorsal raphe nucleus; impairs contextual fear in mice when administered prior to training (0.5 mg/kg, s.c); reduces apnea in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome (50 μg/kg i.p.)