A selective GP-BAR1 agonist (EC50 = 1 μM); reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naive rats; protects against development of endothelial dysfunction by increasing CSE expression and activity and reducing ET-1 gene expression in rat model of cirrhosis; increases Akt-dependent phosphorylation of CSE and eNOS and inhibits ET-1 transcription in vitro; reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
BAR-501 GPBAR1 GPBAR-1 g ET1 M-1 M-2 NE antiinflammatory