A selective inhibitor of the fibroblast growth factor receptor tyrosine kinase (IC50s = 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively); demonstrates antiproliferative activity in tumor cell lines expressing deregulated FGFRs (IC50s = 18-281 nM) and in an FGFR-driven human tumor xenograft model (12.5 mg/kg/day)
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
inhibitors inhibits inhibitions fibroblast growth factors receptors FGFRs tyrosines kinases FGFR1 FGFR2 FGFR3 antiproliferative antitumors 1 2 3 one two three anti-proliferative anti proliferative anti-tumors tumors AZDs 4547 AZD4547 AZD-4547 selective cells lines signal transduction biochemistry proteins cancers