Selectively inhibits checkpoint kinases Chk1 and Chk2 (IC50s = 5 nM); abrogates DNA damage-induced S and G2 checkpoints (EC50 = 10 nM) and potentiates the efficacy of gemcitabine and topotecan by modulating downstream checkpoint pathway proteins
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
1019773-80-8 DNA damage repair checkpoints cells cycles kinases Chk1 Chk2 S phases G2 tumors cancers inhibitors inhibits inhibition AZD-7762 AZD7762 ATP Chk-1 Chk-2 Chk 1 Chk 2