產(chǎn)品名稱 EPZ5676 from CAYMAN CHEMICAL COMPANY
    產(chǎn)品貨號 16175-1
    產(chǎn)品價格 現(xiàn)貨詢價，電話：010-67529703
    產(chǎn)品規(guī)格 1 mg
    產(chǎn)品品牌 CAYMAN CHEMICAL COMPANY
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameEPZ5676
    DescriptionA highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki = 80 pM); inhibits the H3K79 methylation in various human leukemia cell lines (IC50s = 3-5 nM), decreasing MLL-fusion target gene expression and inhibiting proliferation; intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia
    Size1 mg
    Concentrationn/a
    Applicationsn/a
    Other Names1380288-88-9 inhibitors DOT1L histones methyltransferases MLL-rearranged leukemias epigenetics inhibits inhibitions EPZ5676 EPZ 5676 DOT1L domains genes DNA damages repairs cells cycles regulations MLL drugs aminonucleosides expressions translocations intravenous infusions tumors regression rats xenografts EPZ-5676 potent selective H3K79
    Gene, Accession, CAS #CAS: 1380288-87-8
    Catalog #16175-1
    Price
    Order / More InfoEPZ5676 from CAYMAN CHEMICAL COMPANY
    Product Specific Referencesn/a
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