Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of prostaglandins under acute inflammatory conditions.{4,3622} COX-2 is a 72 kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep.{2,7,2884,4051}
Size
1 ea
Concentration
n/a
Applications
Electrophoresis, Western Blot
Other Names
Cyclooxygenase 2|PGHS-2|Prostaglandin H Synthase 2