A potent and selective GPR55 agonist (EC50s = 13, >30,000, and >30,000 for GPR55, CB1, and CB2, respectively); reduces movement-induced firing of nociceptive C fibers in a rat model of inflammatory joint pain; decreases IL-6 and TNF-α levels and myeloperoxidase activities in the plasma, lungs, and pancreas in a mouse model of acute pancreatitis; reduces growth of Mz-ChA-1, HuCCT-1, CCLP-1, and SG231 cholangiocarcinoma cells at a concentration of 50 μM; reduces tumor growth in a Mz-ChA-1 mouse xenograft model; increases food intake and fat mass in rats, however, this effect was also observed in mice lacking GPR55,