Lisinopril is a potent angiotensin converting-Enzyme (ACE) inhibitor (IC50 = 4.7 nM). The administration of lisinopril can lower the diastolic and systolic blood pressure and higher the heart rate. Lisinopril is found to reduce the activity of plasma angiotensin converting enzyme markedly. It increases the level of plasma rennin while decreases the levels of plasma Angiotensin II and aldosterone. MW: 441.52. Purity ≥98% by HPLC