Flow Cytometry: 1:10-1:50, Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000
Reviews / Ratings
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Description
Caspase 5 Polyclonal Antibody. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated
Immunogen
n/a
Other Names
ICE(rel)III, ICEREL-III, ICH-3, CASP-5, ICE(rel)-III, TY protease, caspase 5, apoptosis-related cysteine protease, caspase-5, protease ICH-3, protease TY