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Description
FBW7 Polyclonal Antibody. Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
Immunogen
n/a
Other Names
AGO, archipelago, Archipelago homolog, archipelago homolog (Drosophila), CDC4, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box and WD-40 domain-containing protein 7, F-box protein FBW7, F-box protein FBX30, F-box protein SEL-10, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, hAgo, hCdc4, homolog of C elegans sel-10, SEL10, SEL-10