產(chǎn)品名稱 NSC 319726 from CAYMAN CHEMICAL COMPANY
    產(chǎn)品貨號 23701-25
    產(chǎn)品價格 現(xiàn)貨詢價,電話:010-67529703
    產(chǎn)品規(guī)格 25 mg
    產(chǎn)品品牌 CAYMAN CHEMICAL COMPANY
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameNSC 319726
    DescriptionA p53 reactivator; selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 μM, respectively); induces apoptosis in TOV112D (p53R175H), but not OVCAR3 (p53R248W) or SKOV3 (p53-/-), cells at a concentration of 1 μM; restores a wild-type conformation to human p53175 and mouse p53R172 mutant proteins and induces expression of p53 target genes in TOV112D cells; inhibits tumor growth in TOV112D, but not H460 (p53+/+), mouse xenograft model when administered at a dose of 1 mg/kg; has broad-spectrum antifungal activity (MIC50s = 0.1-2 μg/ml against a panel of pathogenic fungi) with >800-fold selectivity for fungi over human HUH-7 and HepG2 cells
    Size25 mg
    Concentrationn/a
    Applicationsn/a
    Other NamesNSC319726 p-53 p53-R175 R175H R248W R172TOV-112D OVCAR-3 anti-fungal HUH7 Hep-G2 H-460 175 R172 SKOV-3
    Gene, Accession, CAS #CAS: 71555-25-4
    Catalog #23701-25
    Price
    Order / More InfoNSC 319726 from CAYMAN CHEMICAL COMPANY
    Product Specific Referencesn/a
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