Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Western Blot: 1:500-1:2000
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Description
RBP3 Polyclonal Antibody. Interphotoreceptor retinoid-binding protein (IRBP) is a retinoid and fatty acid binding protein expressed exclusively in the photoreceptor cells of the retina and pinealocytes of the pineal gland. The gene encoding human IRBP maps to chromosome 10q11.2. A putative trans-acting complex binds a cis-element in the IRBP promoter and fully activates transcription of the IRBP gene. Hypomethylation of cysteine residues in the IRBP promoters of bovine and murine photoreceptor cells permits expression of the IRBP gene. IRBP may be involved in shuttling retinoids between photoreceptors and the retinal pigment epithelium. IRBP exists as a glycoprotein with a four-fold repeat structure. Each 300 amino acid repeat contains one