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Description
PTGR2 Polyclonal Antibody. ZADH1 (zinc binding alcohol dehydrogenase,domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis an